DYMO Labelwriter 400 series are now certified for Windows Vista:

Certified for Windows Vista products provide superior experiences with your software, photos, music, videos, and online communications on PCs running the Windows Vista operating system.

That’s because only Certified for Windows Vista software and devices have undergone compatibility tests for ease of use, better performance, and enhanced security.

Certified for Windows Vista products make activities like enjoying photos and music, setting up wireless networks, connecting and using printers and completing business tasks faster, easier, and more secure.

Use DYMO labels for superior print quality and Microsoft Windows Vista software for ease of using your Labelwriter 400 series.